(EC) No.1907/2006标准MSDS报告翻译-厂家MSDS报告 原文：
Safety data sheet
Page: 1/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
1. Substance/preparation and company identification
Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
Use: feed additive(s), food additive(s), cosmetic ingredient
Company:
BASF SE
67056 Ludwigshafen
GERMANY
Operating Division Care Chemicals
Telephone: +49 621 60-48643
Telefax number: +49 621 60 66-48643
E-mail address: EM-Masterdata@basf.com
Emergency information:
International emergency number:
Telephone: +49 180 2273-112
2. Hazard identification
No particular hazards known.
3. Composition/information on ingredients
Chemical nature
Vitamin E Acetate
CAS Number: 7695-91-2
EC-Number: 231-710-0
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
4. First-aid measures
General advice:
Remove contaminated clothing.
If inhaled:
Keep patient calm, remove to fresh air.
On skin contact:
Wash thoroughly with soap and water.
On contact with eyes:
Wash affected eyes for at least 15 minutes under running water with eyelids held open.
On ingestion:
Rinse mouth and then drink plenty of water.
Note to physician:
Treatment: Symptomatic treatment (decontamination, vital functions).
5. Fire-fighting measures
Suitable extinguishing media:
water spray, carbon dioxide, dry extinguishing media, foam
Special protective equipment:
Wear a self-contained breathing apparatus.
Further information:
Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
6. Accidental release measures
Personal precautions:
No special precautions necessary.
Environmental precautions:
Do not discharge into drains/surface waters/groundwater.
Methods for cleaning up or taking up:
For small amounts: Pick up with suitable absorbent material.
For large amounts: Pick up with suitable absorbent material.
Dispose of absorbed material in accordance with regulations.
Page: 3/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
7. Handling and storage
Handling
Processing machines must be fitted with local exhaust ventilation. Take precautionary measures
against static discharges. Keep away from sources of ignition - No smoking.
Storage
Further information on storage conditions: Containers should be stored tightly sealed in a dry place.
Protect against heat.
8. Exposure controls and personal protection
Components with workplace control parameters
none
Personal protective equipment
Hand protection:
Suitable chemical resistant safety gloves (EN 374) also with prolonged, direct contact
(Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to
EN 374): E.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), butyl rubber (0.7 mm) and other
Supplementary note: The specifications are based on tests, literature data and information of glove
manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g.
temperature) it must be considered, that the practical usage of a chemical-protective glove in
practice may be much shorter than the permeation time determined through testing.
Eye protection:
Safety glasses with side-shields (frame goggles) (e.g. EN 166)
Body protection:
Body protection must be chosen based on level of activity and exposure.
General safety and hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
9. Physical and chemical properties
Form: oily
Colour: colourless to amber
Odour: almost odourless
Freezing point: -27.5 °C
Boiling range: > 300 °C
Flash point: approx. 210 °C (DIN 51758)
Ignition temperature: approx. 303 °C (DIN 51794)
Page: 4/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
Vapour pressure: approx. 1.4 mbar
(approx. 240 °C)
approx. 4.0 mbar
(approx. 270 °C)
Density: approx. 0.95 - 0.96 g/cm3
(approx. 20 °C)
approx. 0.93 g/cm3
(approx. 60 °C)
Solubility in water: sparingly soluble
Solubility (qualitative) solvent(s): organic solvents
soluble
Partitioning coefficient n-octanol/water (log Pow): 12.26
(25 °C)
(calculated)
Viscosity, dynamic: approx. 700 mPa.s
(approx. 40 °C)
10. Stability and reactivity
Thermal decomposition: > 300 °C
Hazardous reactions:
No hazardous reactions if stored and handled as prescribed/indicated.
Hazardous decomposition products:
No hazardous decomposition products if stored and handled as prescribed/indicated.
11. Toxicological information
Acute toxicity
Assessment of acute toxicity:
Virtually nontoxic after a single ingestion.
LD50 rat (oral): > 10,000 mg/kg (BASF-Test)
Irritation
Assessment of irritating effects:
Not irritating to the skin. Not irritating to the eyes.
Primary skin irritation rabbit: non-irritant (OECD Guideline 404)
Primary irritations of the mucous membrane rabbit: non-irritant (OECD Guideline 405)
Sensitization
Page: 5/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
Assessment of sensitization:
Skin sensitizing effects were not observed in animal studies.
Guinea pig maximization test guinea pig: Non-sensitizing.
Literature data.
Genetic toxicity
Assessment of mutagenicity:
Most of the results from the numerous studies available show no evidence of a mutagenic effect.
Reproductive toxicity
Assessment of reproduction toxicity:
The results of animal studies gave no indication of a fertility impairing effect.
Developmental toxicity
Assessment of teratogenicity:
Fetal toxicity was not observed in animal studies which were performed with methods that do not
fulfill current guidelines.
12. Ecological information
Ecotoxicity
Assessment of aquatic toxicity:
There is a high probability that the product is not acutely harmful to aquatic organisms. No toxic
effects occur within the range of solubility. The inhibition of the degradation activity of activated
sludge is not anticipated when introduced to biological treatment plants in appropriate low
concentrations. The product has not been tested. The statement has been derived from products of
a similar structure and composition.
Toxicity to fish:
LC50 (96 h) > 10,000 mg/l, Leuciscus idus (DIN 38412 Part 15, static)
Tested above maximum solubility. The details of the toxic effect relate to the nominal concentration.
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
Aquatic invertebrates:
EC50 (48 h) > 500 mg/l, Daphnia magna (Directive 79/831/EEC, static)
The product has low solubility in the test medium. An aqueous solution prepared with solubilizers has
been tested. The details of the toxic effect relate to the nominal concentration. The product has not
been tested. The statement has been derived from products of a similar structure and composition.
Microorganisms/Effect on activated sludge:
EC10 (30 min) > 10,000 mg/l, Pseudomonas putida (DIN 38412 Part 27 (draft), aquatic)
The details of the toxic effect relate to the nominal concentration.
EC20 (30 min) > 927 mg/l, activated sludge, domestic (DIN EN ISO 8192, aquatic)
Page: 6/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
Persistence and degradability
Assessment biodegradation and elimination (H2O):
Moderately/partially biodegradable. Not readily biodegradable (by OECD criteria). The product is
virtually insoluble in water and can thus be separated from water mechanically in suitable effluent
treatment plants.
Elimination information:
39 % BOD of the ThOD (28 d) (OECD 301F; ISO 9408; 92/69/EEC, C.4-D) (aerobic, activated
sludge, domestic)
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
Bioaccumulation potential
Bioaccumulation potential:
Because of the n-octanol/water distribution coefficient (log Pow) accumulation in organisms is
possible.
13. Disposal considerations
Observe national and local legal requirements.
14. Transport information
Land transport
ADR
Not classified as a dangerous good under transport regulations
RID
Not classified as a dangerous good under transport regulations
Inland waterway transport
ADNR
Not classified as a dangerous good under transport regulations
Sea transport
IMDG
Not classified as a dangerous good under transport regulations
Air transport
Page: 7/7
BASF Safety data sheet according to Regulation (EC) No.1907/2006
Date / Revised: 06.02.2008 Version: 1.4
Product: Vitamin E-Acetate (DL-alpha-tocopheryl acetate)
(30041054/SDS_GEN_EU/EN)
Date of print 28.05.2008
IATA/ICAO
Not classified as a dangerous good under transport regulations
15. Regulatory information
Regulations of the European union (Labelling) / National legislation/Regulations
EC-Number: 231-710-0
The product does not require a hazard warning label in accordance with EC Directives.
Other regulations
16. Other information
Vertical lines in the left hand margin indicate an amendment from the previous version.
The data contained in this safety data sheet are based on our current knowledge and experience and
describe the product only with regard to safety requirements. The data do not describe the product's
properties (product specification). Neither should any agreed property nor the suitability of the product for
any specific purpose be deduced from the data contained in the safety data sheet. It is the responsibility
of the recipient of the product to ensure any proprietary rights and existing laws and legislation are
observed.
译文：
安全说明书（SDS）
1. 产品及公司信息
维生素E醋酸酯（生育酚乙酸酯）
用途：饲料，食品，化妆品添加剂
公司信息：
BASF SE
67056 Ludwigshafen
德国
护理品经营部
电话：+49 621 60-48643
传真：+49 621 60 66-48643
紧急联络信息：
国际紧系联络电话：
+49 180 2273-112
_______________________________________________________________________
2. 危害识别
未有特殊危害。
_______________________________________________________________________
3. 产品成分信息
化学品属性
维生素E醋酸酯
美国化学文摘社登记号（CAS#）：7695-91-2
欧洲现有商业化学品目录（EC#）：231-710-0
_______________________________________________________________________
4. 急救措施
一般建议：
脱去被污染衣物。
吸入后：
吸入者应保持冷静，撤离至空气清新处。
皮肤接触后：
使用肥皂和水彻底清洗。
眼睛接触后：
撑开眼睑，用流动清水冲洗眼睛至少15分钟。
吞食后：
漱口后，饮足量水稀释。
给医生的建议：
根据症状医治（如：采取净化方法，观察生命机能）。
_______________________________________________________________________
5. 消防措施
合适的灭火介质：
喷水，二氧化碳，干粉及泡沫灭火剂。
特殊防护设备：
佩戴自给式呼吸器。
其它信息：
根据相关法规处理火灾残渣及消防废弃水。
_______________________________________________________________________
6. 意外泄漏处置措施
个人预防措施：
无特殊要求。
环境保护预防措施：
请勿将泄漏物排入排水沟/地表水/地下水。
清洁或收集措施：
少量泄漏：用合适的吸附物质收集
大量泄漏：用合适的吸附物质收集。
根据相关法规处置收集的泄漏物。
_______________________________________________________________________
7. 处置与储存
处置：
加工机器必须配备局部通风装置。采取预防措施避免静电释放。远离火源-禁止吸烟。
储存：
储存条件：容器应密闭，置于干燥的场所。远离热源。
_______________________________________________________________________
8. 接触控制/个人防护
在工作场所需控制接触极限值的成分：
无。
个人防护设备：
手部防护：
对于长时间或直接接触，选用合适的化学防护手套（EN 374标准）。
建议：参照EN 374规定，在渗透时间长于480分钟，防护指数为6的情况下，可选用以下材质的手套：丁腈橡胶手套（0.4mm厚），氯丁橡胶手套（0.5mm厚），丁基橡胶手套（0.7mm厚）及其它合适的手套。
备注：上述建议基于相关测试，文献资料及手套厂家提供的信息或且根据同类产品而总结得出。鉴于许多必须要考虑到的条件（如：温度），化学防护手套的实际使用时间可能远远短于测试得出的渗透时间。
眼睛防护：
佩戴两侧带有防护的安全防护眼镜（护目镜）（如：符合EN 166标准的防护镜）
身体防护：
身体防护设备的选择取决于实际作业及接触情况。
基本安全与卫生措施：
参照良好的工业卫生及安全条例操作。
_______________________________________________________________________
9. 理化特性
外表：油状物
颜色：无色或黄褐色
气味：近乎无味
凝固点：-27.5℃
沸点：＞300℃
闪点：约210℃ （DIN 51758）
引燃温度：约303℃ （DIN 51794）
蒸汽压：约1.4 mbar
（温度约240℃）
约4.0 mbar
(温度约270℃)
密度：约0.95-0.96g/cm3
(温度约20℃)
约0.93g/cm3
(温度约60℃)
水溶性：微溶
溶解溶剂：溶于有机溶剂
在25℃时的辛醇/水分配系数的对数值：12.26
动态粘性：约700 mPa.s
(温度约40℃)
_______________________________________________________________________
10. 稳定性与反应性
热分解温度：＞300℃
危险反应：
根据指定或规定的要求进行存放及操作，不会发生危险反应。
有害分解产物：
根据指定或规定的要求进行存放及操作，不会产生有害分解产物。
如需MSDS报告翻译，欢迎联系本站！
_______________________________________________________________________
11. 毒性数据
急性毒性：
关于急性毒性的评估：
单次吞食，实际无毒。
LD50大鼠经口：＞1,0000 mg/kg（经BAST测试）
刺激性
刺激性评估：
对皮肤，眼睛无刺激性。
皮肤刺激测试（家兔）：无刺激（OECD 404指标）
黏膜刺激性测试（家兔）：无刺激（OECD 405指标）
致敏性
关于致敏性的评估：
在动物研究测试中，未发现致敏性。
豚鼠最大化试验：未发现致敏性 （参考文献资料）
遗传毒性
关于致突变性的评估：
根据大量现有的研究结果，未发现致突变效应。
生殖毒性
关于生殖毒性的评估：
根据现有的动物研究报告，未发现生殖损害影响。
发育毒性
关于致畸性的评估：
根据动物研究测试，未发现胚胎毒性，但该测试未按照当前的测试规定操作。
备注：
LD50：半数致死量
OECD：经济合作与发展组织
_______________________________________________________________________
12. 生态数据
生态毒性
关于水生物毒性的评估：
该产品对水生物不具有急性毒性，其溶于水中不会产生毒性。当低浓度的类似物质置于生物处理设备中，活性污泥并没有对降解起到抑制作用。未对该产品做测试，该结论针对结构和成分类似的产品。
对鱼类的毒性：
LC50（96h）＞1,0000 mg/l，圆腹雅罗鱼（参照DIN 38412-15，静态鱼类）
上述测得的未最大溶解度。关于具体的毒性效应取决于规定的浓度。未对该产品做测试，该结论针对结构和成分类似的产品。
水生无脊椎动物：
EC50（48h）＞500 mg/l，大型蚤（参照指令79/831/EEC，静态水生物）
在测试介质中的溶解性很低，在增加了增溶剂的水溶液中进行了测试。关于具体的毒性效应取决于规定的浓度。未对该产品做测试，该结论针对结构和成分类似的产品。
微生物对活性污泥产生的效应：
EC10（30min）＞500 mg/l，恶臭假单胞菌（参照DIN 38412-27（草案），水生环境中）
关于具体的毒性效应取决于规定的浓度。
EC20（30min）＞927 mg/l，活性污泥（参照 DIN EN ISO8192，水生环境中）
持续性及生物降解性
关于在水中的生物降解性及消除的评估：
中度/部分降解。不易降解（参照OECD制定的标准）。该产品在水中实际不溶，在废水处理设备中可被机械性分散。
消除信息
39% ThOD BOD (28d) (参照OECD 301F；ISO 9408；92/69/EEC，C.4-D) （活性污泥，有氧环境中）
未对该产品做测试，该结论针对结构和成分类似的产品。
生物聚集性
从辛醇/水分配系数来看，有可能产生生物聚积。
备注：
LC50：在动物急性毒性试验中，使受试动物半数死亡的毒物浓度。
EC50/20/10：药物安全性指标，指引起50%/20%/10%个体有效的剂量扩大多少倍，才会导致50%/20%/10%的个体死亡（或中毒）。
DIN：德国标准化学会
OECD：经济合作与发展组织
BOD：生化需氧量
ThOD：理论需氧量
_______________________________________________________________________
13. 废弃处置
参照国家及当地相关法规处置。
_______________________________________________________________________
14. 运输资料
陆地运输
欧洲国际公路运输危险货物协定（ADR） 该物质未列为危险运输货物。
国际铁路运输危险货物条例（RID） 该物质未列为危险运输货物。
内河航道运输
欧洲危险货物内河运输条例（ADNR） 该物质未列为危险运输货物。
海运
国际海上危险货物规则（IMDG） 该物质未列为危险运输货物。
空运
国际航空运输协会/国际民航组织（IATA/ICAO）该物质未列为危险运输货物。
_______________________________________________________________________
15. 法规信息
欧盟法规（标签）/国内立法/法规
欧洲现有商业化学品目录（EC#）：231-710-0
该产品无须参照EC指令做危害警示标签。
其它信息
_______________________________________________________________________
16. 其它信息
左边页边空白处标示的垂直线表明对之前版本的报告作了修改。
该安全说明书中的数据是基于我们现有认知水平及经验之上而提供的，且只针对产品安全要求，并不针对产品特性（产品规格）。该安全说明书中的数据并不对产品特性或产品特殊用途的适用性做任何担保。应该产品使用者来确保产品所有权及遵守现行相关法规及立法。
如需MSDS报告翻译，欢迎联系本站！ |
